FastaLake
downstream-application · Hybrid de novo + database search
FastaLake: downstream-application · Hybrid de novo + database search. Metaproteomics workflow that uses full-length AlphaNovo de novo peptide predictions as exact queries to select compact search databases from large sequence reservoirs…
Metaproteomics workflow that uses full-length AlphaNovo de novo peptide predictions as exact queries to select compact search databases from large sequence reservoirs, then searches them with Sage. Matched metagenome-derived databases in two stool cohorts and found 20-35% more peptides in intestinal fluid, without matched metagenomic sequencing.
| Kind | downstream-application |
| Deep learning | yes |
| Acquisition | DDA |
| Family | Hybrid de novo + database search |
| Application area | Metaproteomics |
Code
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Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.