Hot ECD w-ion Leu/Ile discrimination
adjacent · Fragment ion analysis
Hot ECD w-ion Leu/Ile discrimination: adjacent · Fragment ion analysis. Uses secondary side-chain losses in hot electron capture dissociation, formed through a gamma-lactam ring, to tell isoleucine from leucine, which ordinary de novo…
Uses secondary side-chain losses in hot electron capture dissociation, formed through a gamma-lactam ring, to tell isoleucine from leucine, which ordinary de novo sequencing cannot do.
| Kind | adjacent |
| Deep learning | no |
| Family | Fragment ion analysis |
Paper describing it
- Secondary Losses via γ-Lactam Formation in Hot Electron Capture Dissociation: A Missing Link to Complete de Novo Sequencing of Proteins? (2003, Journal of the American Chemical Society, peer-reviewed)