Thioether macrocycle oxidative linearization
adjacent · Chemical derivatization assisted
Thioether macrocycle oxidative linearization: adjacent · Chemical derivatization assisted. Oxidising the thioether of a thioether-closed macrocyclic peptide makes collision-induced dissociation open the ring at one site, so the linearised peptide…
Oxidising the thioether of a thioether-closed macrocyclic peptide makes collision-induced dissociation open the ring at one site, so the linearised peptide can be sequenced de novo; demonstrated on a randomised macrocycle library.
| Kind | adjacent |
| Deep learning | no |
| Acquisition | DDA |
| Family | Chemical derivatization assisted |
Paper describing it
- Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides (2024, Chemical Communications, peer-reviewed)