BiATNovo
algorithm · Transformer (AR)
Bidirectional self-attention
| Kind | algorithm |
| Deep learning | yes |
| Acquisition | both |
| Family | Transformer (AR) |
Code
Live stars, open issues and last-push figures are on the Code activity chart.
Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.
Trained on
- DIA_urine_proteomics_biomarker_discovery_abdominal-pain (as deposited) · 2023 preprint, 2024 preprint
- Nine-species benchmark (original (DeepNovo, 2017)) · 2023 preprint, 2024 preprint
Evaluated on
- De novo sequencing of DIA data (version not stated) · 2023 preprint, 2024 preprint
- Nine-species benchmark (original (DeepNovo, 2017)) · 2023 preprint, 2024 preprint
Benchmarks
- denovo_benchmarks: median peptide-level average precision 0.469 over 86 datasets, median rank 12 of 15 (version bm-1.0.0).
Both are mass-based matches on the tool’s most recent run. What these numbers mean.
Reported comparisons (2)
The comparison tables this method’s own papers print, standardised: every value on a 0-1 scale, methods down the side, the measure and then the species across. These are numbers papers report about themselves and their baselines. They are not a leaderboard, and they do not compare across tables: each was produced by a different group, on the dataset named in its corner, with each baseline either retrained, run from released weights or quoted from another paper. Where the paper says which, it follows the method’s name (hover it for the sentence); most papers do not say. Bold is the best value in a column and underline the runner-up, our ranking rather than the paper’s own marks.
Table 2
BiATNovo: A Self-Attention based Bidirectional Peptide Sequencing Method, page 7: Results of BiATNovo and Baseline.
| De novo sequencing of DIA data | Amino acid precision | Amino acid recall | Peptide precision | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OC | UTI | Plasma | OC | UTI | Plasma | OC | UTI | Plasma | |
| DeepNovo-DIA | 0.6812 | 0.6581 | 0.6379 | 0.6822 | 0.6598 | 0.6430 | 0.5240 | 0.5106 | 0.3740 |
| BiATNovo | 0.7457 | 0.7078 | 0.6628 | 0.7513 | 0.7151 | 0.6707 | 0.6147 | 0.5760 | 0.4364 |
Table 2
BiATNovo: An Attention-based Bidirectional De Novo Sequencing Framework for Data-Independent-Acquisition Mass Spectrometry, page 8: Comparison of DeepNovo-DIA, PepNet and BiATNovo
| De novo sequencing of DIA data | Amino acid precision | Amino acid recall | Peptide precision | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OC | UTI | Plasma | OC | UTI | Plasma | OC | UTI | Plasma | |
| DeepNovo-DIA | 0.5562 | 0.6286 | 0.4354 | 0.5596 | 0.6243 | 0.4335 | 0.5098 | 0.5525 | 0.3322 |
| BiATNovo | 0.6817 | 0.7108 | 0.4525 | 0.6746 | 0.7076 | 0.4511 | 0.6439 | 0.6584 | 0.3691 |
| PepNet | 0.4008 | 0.4004 | 0.3064 | ||||||
Papers describing it (2)
- BiATNovo: A Self-Attention based Bidirectional Peptide Sequencing Method (2023, bioRxiv, preprint)
- BiATNovo: An Attention-based Bidirectional De Novo Sequencing Framework for Data-Independent-Acquisition Mass Spectrometry (2024, bioRxiv, preprint)