PLMNovo
algorithm · Transformer (AR)
PLMNovo: algorithm · Transformer (AR). Casts peptide-spectrum matching as a constrained optimisation that aligns the spectrum encoder’s embeddings with those of a pre-trained protein language model, and…
Casts peptide-spectrum matching as a constrained optimisation that aligns the spectrum encoder’s embeddings with those of a pre-trained protein language model, and trains encoder and decoder with a Lagrangian primal-dual algorithm, optionally fine-tuning the language model.
| Kind | algorithm |
| Deep learning | yes |
| Acquisition | DDA |
| Family | Transformer (AR) |
Paper describing it
- Protein Language Model-Aligned Spectra Embeddings for De Novo Peptide Sequencing (2025, bioRxiv, preprint)