T-Bruijn graph top-down de novo sequencing
algorithm · Graph / DP
T-Bruijn graph top-down de novo sequencing: algorithm · Graph / DP. De novo sequencing from TOP-DOWN spectra, where the whole protein is fragmented rather than tryptic peptides: derives sequence tags and assembles them through a T-Bruijn…
De novo sequencing from TOP-DOWN spectra, where the whole protein is fragmented rather than tryptic peptides: derives sequence tags and assembles them through a T-Bruijn graph, evaluated on carbonic anhydrase 2 and an alemtuzumab Fab.
| Kind | algorithm |
| Deep learning | no |
| Acquisition | DDA |
| Family | Graph / DP |
Papers describing it (3)
- De Novo Sequencing of Peptides from Top-Down Tandem Mass Spectra (2015, Journal of Proteome Research, peer-reviewed)
- De Novo Sequencing of Peptides from High‐Resolution Bottom‐Up Tandem Mass Spectra using Top‐Down Intended Methods (2017, PROTEOMICS, peer-reviewed)
- Application of Top-Down Deconvolution Tools to Bottom-Up Mass Spectrometry Data: Advantages and Limitations (2022, Springer Proceedings in Physics, peer-reviewed)