Top-down plus bottom-up de novo protein sequencing

algorithm · Spectral alignment / assembly

Top-down plus bottom-up de novo protein sequencing: algorithm · Spectral alignment / assembly. Uses top-down spectra of the intact protein as a scaffold to assemble bottom-up de novo peptide reads into a full protein sequence.

Uses top-down spectra of the intact protein as a scaffold to assemble bottom-up de novo peptide reads into a full protein sequence.

Kind	algorithm
Deep learning	no
Acquisition	DDA
Family	Spectral alignment / assembly

Paper describing it

• De Novo Protein Sequencing by Combining Top-Down and Bottom-Up Tandem Mass Spectra (2014, Journal of Proteome Research, peer-reviewed)

Authors (12)

Xiaowen Liu, Lennard J. M. Dekker, Si Wu, Martijn M. VanDuijn, Theo M. Luider, Nikola Tolić, Qiang Kou, Mikhail Dvorkin, Sonya Alexandrova, Kira Vyatkina, Ljiljana Paša-Tolić, Pavel A. Pevzner

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