Can we Confidently Sequence the „Peptide Dark Matter“? Reaching a Consensus for De Novo Peptide Sequencing

presentation · Proceedings of the 38th European Peptide Symposium · 2026

presentation · Proceedings of the 38th European Peptide Symposium · 2026. Sebastian Johannes Eder et al.
Date 2026-09-24
Type presentation
Venue Proceedings of the 38th European Peptide Symposium
Publisher The European Peptide Society
Contribution post-processor
DOI 10.17952/38eps.2026.p270
Citations (OpenAlex) 0

Authors

  1. Sebastian Johannes Eder · University of Vienna
  2. Manuela Schmidt · University of Vienna
  3. David Gómez-Varela · University of Vienna

Methods and tools

  • QUORUM: Consensus de novo caller with FDR control: runs Casanovo, InstaNovo and PrimeNovo on the same spectrum, scores every aligned residue with a gradient-boosted model from inter-model agreement, ion evidence class and retention-time error, assembles a fourth candidate and picks among the four with a logistic-regression selector.

Methods it uses

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