Delineating the venom toxin arsenal of Malabar pit viper (Trimeresurus malabaricus) from the Western Ghats of India and evaluating its immunological cross-reactivity and in vitro cytotoxicity

peer-reviewed · International Journal of Biological Macromolecules · 2020

peer-reviewed · International Journal of Biological Macromolecules · 2020. Muralidharan Vanuopadath et al.
Date 2020-01-23
Type peer-reviewed
Venue International Journal of Biological Macromolecules
Publisher Elsevier
Contribution downstream-application
DOI 10.1016/j.ijbiomac.2020.01.226
Citations (OpenAlex) 28

Authors

  1. Muralidharan Vanuopadath · Amrita Vishwa Vidyapeetham
  2. Sanu Korumadathil Shaji · Amrita Vishwa Vidyapeetham
  3. Dileepkumar Raveendran · Indriyam Biologics Pvt. Ltd., University of Kerala
  4. Bipin Gopalakrishnan Nair · Amrita Vishwa Vidyapeetham
  5. Sudarslal Sadasivan Nair · Amrita Vishwa Vidyapeetham

Methods and tools

  • Malabar pit viper venomics: Venomics workflow combining SDS-PAGE and ion-exchange pre-fractionation with LC-MS/MS + Novor and PEAKS de novo sequencing to identify 97 proteins (including 18 exclusive to de novo) from Trimeresurus malabaricus venom, and evaluate antivenom cross-reactivity.
  • Novor: Real-time decision-tree scoring
  • PEAKS: Commercial DP-based de novo

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