Novor
algorithm · Decision tree
Real-time decision-tree scoring
| Kind | algorithm |
| Deep learning | no |
| Acquisition | DDA |
| Family | Decision tree |
Data
What the papers describing this method trained it on and reported its results on, as each paper states it. A version is named only where the paper names one.
Also used, purpose not recorded
Benchmarks
- denovo_benchmarks: median peptide-level average precision 0.825 over 86 datasets, median rank 4 of 15 (version v5.1.5-b302).
Both are mass-based matches on the tool’s most recent run. What these numbers mean.
Compared against in other papers (2)
4 tables from 2 papers that report this method as a baseline, newest first. The caveats of the comparisons above hold twice over: each paper ran, retrained or quoted this method its own way, so its number here is that paper’s claim, not a measurement of the method. Where a paper says which it did, the word follows the method’s name.
LIPNovo+: Self-Reflective Latent Imputation for Robust De Novo Peptide Sequencing (2026) · 1 table
Table5
LIPNovo+: Self-Reflective Latent Imputation for Robust De Novo Peptide Sequencing, page 18: Comparison with state-of-the-art methods on GraphNovo dataset [11].
| GraphNovo dataset and checkpoint | Peptide recall | Peptide AUC | Amino acid recall | Amino acid precision |
|---|---|---|---|---|
| PEAKS | 0.475 | 0.758 | 0.775 | |
| Novor | 0.431 | 0.740 | 0.753 | |
| DeepNovo | 0.497 | 0.769 | 0.771 | |
| PointNovo | 0.601 | 0.815 | 0.816 | |
| Casanovo · retrained | 0.605 | 0.684 | 0.684 | |
| GraphNovo | 0.712 | 0.876 | 0.874 | |
| LIPNovo | 0.729 | 0.707 | 0.876 | 0.882 |
| LIPNovo+ | 0.740 | 0.720 | 0.889 | 0.891 |
pNovo 3: precise de novo peptide sequencing using a learning-to-rank framework (2019) · 3 tables
Table2 (QE_HF_X2)
pNovo 3: precise de novo peptide sequencing using a learning-to-rank framework, page 5: Recall of top-1 peptides identified by different de novo sequencing algorithms
|
HeLa Q Exactive HF runs (pNovo 3) QE_HF_X2 |
Peptide recall |
|---|---|
| pNovo 3 | 0.383 |
| pNovo · quoted | 0.214 |
| PEAKS · quoted | 0.246 |
| Novor | 0.093 |
Table2 (QE_HF_X1)
pNovo 3: precise de novo peptide sequencing using a learning-to-rank framework, page 5: Recall of top-1 peptides identified by different de novo sequencing algorithms
|
HeLa Q Exactive HF runs (pNovo 3) QE_HF_X1 |
Peptide recall |
|---|---|
| pNovo 3 | 0.478 |
| pNovo · quoted | 0.298 |
| PEAKS · quoted | 0.322 |
| Novor | 0.109 |
Table2 (Nine-species)
pNovo 3: precise de novo peptide sequencing using a learning-to-rank framework, page 5: Recall of top-1 peptides identified by different de novo sequencing algorithms
| Nine-species benchmark | Peptide recall | ||||
|---|---|---|---|---|---|
| Vigna mungo | Mus musculus | Methanosarcina mazei | Saccharomyces cerevisiae | Apis mellifera | |
| pNovo 3 | 0.646 | 0.504 | 0.660 | 0.647 | 0.625 |
| pNovo · quoted | 0.429 | 0.257 | 0.424 | 0.477 | 0.367 |
| PEAKS · quoted | 0.443 | 0.249 | 0.424 | 0.500 | 0.380 |
| Novor | 0.174 | 0.097 | 0.191 | 0.191 | 0.137 |
Papers describing it (2)
- Novor: Real-Time Peptide de Novo Sequencing Software (2015, Journal of the American Society for Mass Spectrometry, peer-reviewed)
- Adjacent Y-Ion Ratio Distributions and Its Application in Peptide Sequencing (2019, IEEE/ACM Transactions on Computational Biology and Bioinformatics, peer-reviewed)
Papers using it (12)
Applications and evaluations that ran this method. They are not counted among its authors below.
- SequenceAssembler: A tool for protein sequence assembly from mass spectrometry data (2025, Journal of Proteomics, peer-reviewed)
- Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child (2025, Proceedings of the National Academy of Sciences, peer-reviewed)
- Venomics and antivenomics of Indian spectacled cobra (Naja naja) from the Western Ghats (2022, Acta Tropica, peer-reviewed)
- DDASSQ: An open‐source, multiple peptide sequencing strategy for label free quantification based on an OpenMS pipeline in the KNIME analytics platform (2021, PROTEOMICS, peer-reviewed)
- Parallel Factor Analysis Enables Quantification and Identification of Highly Convolved Data-Independent-Acquired Protein Spectra (2020, Patterns, peer-reviewed)
- Parallel factor analysis enables quantification and identification of highly-convolved data independent-acquired protein spectra (2020, bioRxiv, preprint)
- Delineating the venom toxin arsenal of Malabar pit viper (Trimeresurus malabaricus) from the Western Ghats of India and evaluating its immunological cross-reactivity and in vitro cytotoxicity (2020, International Journal of Biological Macromolecules, peer-reviewed)
- Algorithm of Protein Sequence Determination by Combination of the Edman Degradation Method and Shotgun Mass Spectrometry (2018, Biomedical Chemistry: Research and Methods, peer-reviewed)
- Mass spectrometry-assisted venom profiling of Hypnale hypnale found in the Western Ghats of India incorporating de novo sequencing approaches (2018, International Journal of Biological Macromolecules, peer-reviewed)
- The sequence coverage in different methods of mass spectrometry data analysis obtained on model proteins (2017, Biomeditsinskaya Khimiya, peer-reviewed)
- Discovery of New Features for Peptide Sequencing with Mass Spectrometry (2017, thesis)
- Tagger: Enhance Database Search Tools with De Novo Sequencing Tags (2017, thesis)