De novo sequence-ambiguity benchmark
benchmark
De novo sequence-ambiguity benchmark: benchmark. Benchmark across 8 leading DL de novo peptide sequencers on three proteomics datasets, showing large overlap of correct calls between models and that post-processing…
Benchmark across 8 leading DL de novo peptide sequencers on three proteomics datasets, showing large overlap of correct calls between models and that post-processing yields only modest gains. The shared error source is limited fragment-ion coverage, a bottleneck that database search shares as well.
| Kind | benchmark |
Papers
- Limitations of de novo sequencing in resolving sequence ambiguity (2025, bioRxiv, preprint)