InstaNovo+

algorithm · Diffusion

InstaNovo+: algorithm · Diffusion. Multinomial diffusion

Multinomial diffusion

Kind	algorithm
Deep learning	yes
Acquisition	DDA
Family	Diffusion

Code

• https://github.com/instadeepai/instanovo

Live stars, open issues and last-push figures are on the Code activity chart.

Papers describing it (2)

• De novo peptide sequencing with InstaNovo: Accurate, database-free peptide identification for large scale proteomics experiments (2023, bioRxiv, preprint)
• InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments (2025, Nature Machine Intelligence, peer-reviewed)

Papers using it (2)

Applications and evaluations that ran this method. They are not counted among its authors below.

• Lactation-stage specific protein shifts in koala milk mirror the joey’s growth needs (2026, International Journal of Biological Macromolecules, peer-reviewed)
• Characterisation of pouch secretions from breeding Tasmanian devils (2026, Reproduction, peer-reviewed)

Authors (19)

Kevin Eloff, Konstantinos Kalogeropoulos, Oliver Morell, Amandla Mabona, Jakob Berg Jespersen, Wesley Williams, Sam P. B. van Beljouw, Marcin J. Skwark, Andreas Hougaard Laustsen, Stan J. J. Brouns, Anne Ljungars, Erwin M. Schoof, Jeroen Van Goey, Ulrich auf dem Keller, Karim Beguir, Nicolas Lopez Carranza, Timothy P. Jenkins, Rachel Catzel, Esperanza Rivera-de-Torre

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