NRP dereplication and sequencing

algorithm · Spectral alignment / assembly

NRP dereplication and sequencing: algorithm · Spectral alignment / assembly. Sequences cyclic nonribosomal peptides from multistage mass spectrometry by spectral alignment, and dereplicates them comparatively against known NRPs. The first…

Sequences cyclic nonribosomal peptides from multistage mass spectrometry by spectral alignment, and dereplicates them comparatively against known NRPs. The first high-throughput route to a compound class with no genome to search and considerable pharmacological interest.

Kind	algorithm
Deep learning	no
Acquisition	DDA
Family	Spectral alignment / assembly

Paper describing it

• Dereplication and de novo sequencing of nonribosomal peptides (2009, Nature Methods, peer-reviewed)

Authors (9)

Julio Ng, Nuno Bandeira, Wei-Ting Liu, Majid Ghassemian, Thomas L Simmons, William H Gerwick, Roger Linington, Pieter C Dorrestein, Pavel A Pevzner

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