NRP dereplication and sequencing
algorithm · Spectral alignment / assembly
NRP dereplication and sequencing: algorithm · Spectral alignment / assembly. Sequences cyclic nonribosomal peptides from multistage mass spectrometry by spectral alignment, and dereplicates them comparatively against known NRPs. The first…
Sequences cyclic nonribosomal peptides from multistage mass spectrometry by spectral alignment, and dereplicates them comparatively against known NRPs. The first high-throughput route to a compound class with no genome to search and considerable pharmacological interest.
| Kind | algorithm |
| Deep learning | no |
| Acquisition | DDA |
| Family | Spectral alignment / assembly |
Papers describing it (4)
- De Novo Sequencing of Nonribosomal Peptides (2008, Lecture Notes in Computer Science, peer-reviewed)
- Dereplication and de novo sequencing of nonribosomal peptides (2009, Nature Methods, peer-reviewed)
- Multiplex De Novo Sequencing of Peptide Antibiotics (2011, Lecture Notes in Computer Science, peer-reviewed)
- Multiplex De Novo Sequencing of Peptide Antibiotics (2011, Journal of Computational Biology, peer-reviewed)