PhysNovo

algorithm · Diffusion

PhysNovo: algorithm · Diffusion. Discrete-diffusion de novo peptide sequencer that folds in physical mass-constraint terms at inference time, so generated sequences respect the observed precursor mass…

Discrete-diffusion de novo peptide sequencer that folds in physical mass-constraint terms at inference time, so generated sequences respect the observed precursor mass rather than relying purely on the learned amino-acid prior.

Kind	algorithm
Family	Diffusion
Deep learning	yes

Code

• https://github.com/WanyuGroup/ICML2026_PhysNovo

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Papers

• Discrete Diffusion with Physical Mass Constraints for De Novo Peptide Sequencing (2026, ICML 2026, ML conference)

Authors (2)

Zeyu An, Wanyu Lin

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