ADEPTS: Advanced peptide de novo sequencing with a pair of tandem mass spectra

peer-reviewed · Journal of Bioinformatics and Computational Biology · 2010

peer-reviewed · Journal of Bioinformatics and Computational Biology · 2010. Lin He et al. De novo sequencing is an important task in proteomics to identify novel peptide sequences. Traditionally…
Date 2010-12-01
Type peer-reviewed
Venue Journal of Bioinformatics and Computational Biology
Publisher World Scientific Pub Co Pte Ltd
Contribution algorithm
DOI 10.1142/S0219720010005099
Citations (OpenAlex) 32
Venue 2-year citedness 0.89

Abstract

De novo sequencing is an important task in proteomics to identify novel peptide sequences. Traditionally, only one MS/MS spectrum is used for the sequencing of a peptide; however, the use of multiple spectra of the same peptide with different types of fragmentation has the potential to significantly increase the accuracy and practicality of de novo sequencing. Research into the use of multiple spectra is in a nascent stage. We propose a general framework to combine the two different types of MS/MS data. Experiments demonstrate that our method significantly improves the de novo sequencing of existing software.

Authors

  1. Lin He · Bioinformatics Solutions Inc., University of Waterloo
  2. Bin Ma · Rapid Novor Inc., University of Waterloo, University of Western Ontario, Western University

Methods and tools

  • ADEPTS: Advanced peptide de novo sequencing framework using a pair of tandem mass spectra.

Cites (5)

Cited by (20)

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