De Novo Sequencing of Proteins and Peptides: Algorithms, Applications, Perspectives

peer-reviewed · Biomedical Chemistry: Research and Methods · 2018

peer-reviewed · Biomedical Chemistry: Research and Methods · 2018. Kira Vyatkina. Determination of the primary structure of proteins and peptides constitutes an important step in studying…
Date 2018-01-01
Type peer-reviewed
Venue Biomedical Chemistry: Research and Methods
Publisher Institute of Biochemistry
Contribution review
DOI 10.18097/bmcrm00005
Citations (OpenAlex) 1
Venue 2-year citedness 0.48

Abstract

Determination of the primary structure of proteins and peptides constitutes an important step in studying their properties. Currently, mass spectrometry is commonly applied to this end. The results of mass spectrometric measurements can be interpreted by means of either a database search or de novo sequencing methods. The appeal of the latter is due to their applicability to investigating unknown proteins, as well as the ones that cannot be analyzed with genomics or transcriptomics methods. In this paper, we briefly review the existing approaches to de novo sequencing of proteins and peptides, along with the problems that can be solved using those, and indicate directions and perspectives for their further development.

Authors

  1. Kira Vyatkina · ITMO University, Saint Petersburg Academic University, Saint Petersburg National Research Academic University of the Russian Academy of Sciences, Saint Petersburg State Electrotechnical University, St Petersburg University, St. Petersburg State University

Methods and tools

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Cited by (1)

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