Identification of short single disulfide-containing contryphans from the venom of cone snails using de novo mass spectrometry-based sequencing methods
peer-reviewed · Toxicon · 2017
peer-reviewed · Toxicon · 2017. Jayaseelan B. Franklin et al. We identified 12 short single disulfide-containing conopeptides from the venom of Conus coronatus, C…
| Date | 2017-06-01 |
| Type | peer-reviewed |
| Venue | Toxicon |
| Publisher | Elsevier BV |
| Contribution | downstream-application |
| DOI | 10.1016/j.toxicon.2017.04.003 |
| Citations (OpenAlex) | 6 |
| Venue 2-year citedness | 1.78 |
Abstract
We identified 12 short single disulfide-containing conopeptides from the venom of Conus coronatus, C. leopardus, C. lividus and C. zonatus. Interestingly, we detected the shortest contryphan sequence thus far characterized which contains only six amino acid residues. We also identified three distinct contryphan sequences of C. lividus without any proline residues and one sequence with an unusual post-translational modification (bromination of tryptophan). Furthermore, we characterized venom peptides of C. zonatus for the first time.
Methods and tools
- Cone snail contryphans: De novo sequencing of twelve short single-disulfide conopeptides from four cone snail species, including the shortest contryphan characterised and one with a brominated tryptophan.