FT‐MS in the de novo top‐down sequencing of natural nontryptic peptides
peer-reviewed · Mass Spectrometry Reviews · 2022
peer-reviewed · Mass Spectrometry Reviews · 2022. Albert T. Lebedev et al. The present review covers available results on the application of FT-MS for the de novo sequencing of natural…
| Date | 2022-03-01 |
| Type | peer-reviewed |
| Venue | Mass Spectrometry Reviews |
| Publisher | Wiley |
| Contribution | review |
| DOI | 10.1002/mas.21678 |
| Citations (OpenAlex) | 22 |
| Venue 2-year citedness | 4.29 |
Abstract
The present review covers available results on the application of FT-MS for the de novo sequencing of natural peptides of various animals: cones, bees, snakes, amphibians, scorpions, and so forth. As these peptides are usually bioactive, the animals efficiently use them as a weapon against microorganisms or higher animals including predators. These peptides represent definite interest as drugs of future generations since the mechanism of their activity is completely different in comparison with that of the modern antibiotics. Utilization of those peptides as antibiotics can eliminate the problem of the bacterial resistance development. Sequence elucidation of these bioactive peptides becomes even more challenging when the species genome is not available and little is known about the protein origin and other properties of those peptides in the study. De novo sequencing may be the only option to obtain sequence information. The benefits of FT-MS for the top-down peptide sequencing, the general approaches of the de novxxo sequencing, the difficult cases involving sequence coverage, isobaric and isomeric amino acids, cyclization of short peptides, the presence of posttranslational modifications will be discussed in the review.
Methods and tools
- FT-MS top-down natural peptide review: Review of FT-MS in the de novo top-down sequencing of natural nontryptic peptides from cones, bees, snakes, amphibians and scorpions.
Cites (32)
- Deciphering the Molecular Diversity of an Ant Venom Peptidome through a Venomics Approach (2018) crossref
- Identification of <10 KD peptides in the water extraction of Venenum Bufonis from Bufo gargarizans using Nano LC-MS/MS and De novo sequencing (2018) crossref
- Complete de novo sequencing of antimicrobial peptides in the venom of the scorpion Isometrus maculatus (2017) crossref
- A multi-protease, multi-dissociation, bottom-up-to-top-down proteomic view of the Loxosceles intermedia venom (2017) crossref
- Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry (2017) crossref
- Peptidomics of Acanthoscurria gomesiana spider venom reveals new toxins with potential antimicrobial activity (2017) crossref
- LTQ Orbitrap Velos in routine de novo sequencing of non‐tryptic skin peptides from the frog Rana latastei with traditional and reliable manual spectra interpretation (2016) crossref
- Large Scale Discovery and De Novo-Assisted Sequencing of Cationic Antimicrobial Peptides (CAMPs) by Microparticle Capture and Electron-Transfer Dissociation (ETD) Mass Spectrometry (2015) crossref
- De novo sequencing of two novel peptides homologous to calcitonin-like peptides, from skin secretion of the Chinese Frog, Odorrana schmackeri (2015) crossref
- Venom Proteomics of Indonesian King Cobra, Ophiophagus hannah: Integrating Top-Down and Bottom-Up Approaches (2015) crossref
- Protein and Peptide Composition of Male Accessory Glands of Apis mellifera Drones Investigated by Mass Spectrometry (2015) crossref
- Lessons in de novo peptide sequencing by tandem mass spectrometry (2015) crossref
- Mass spectrometric de novo sequencing of natural non‐tryptic peptides: comparing peculiarities of collision‐induced dissociation (CID) and high energy collision dissociation (HCD) (2014) crossref
- Discrimination of Leucine and Isoleucine in Peptides Sequencing with Orbitrap Fusion Mass Spectrometer (2014) crossref
- Moving Pieces in a Venomic Puzzle: Unveiling Post-translationally Modified Toxins from Tityus serrulatus (2013) crossref
- High-definition De Novo Sequencing of Crustacean Hyperglycemic Hormone (CHH)-family Neuropeptides (2012) crossref
- Constrained De Novo Sequencing of Conotoxins (2012) crossref
- Partial De Novo Sequencing and Unusual CID Fragmentation of a 7 kDa, Disulfide-Bridged Toxin (2012) crossref
- Isolation and sequence analysis of peptides from the skin secretion of the Middle East tree frog Hyla savignyi (2010) crossref
- Characterization of a peptide family from the skin secretion of the Middle East Tree Frog Hyla savignyi by composition‐based de novo sequencing (2010) crossref
- N-terminal tagging strategy forDe Novosequencing of short peptides by ESI-MS/MS and MALDI-MS/MS (2010) crossref
- Combining Bottom-Up and Top-Down Mass Spectrometric Strategies for De Novo Sequencing of the Crustacean Hyperglycemic Hormone from Cancer borealis (2009) crossref
- De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda (2008) crossref
- Oxidation versus carboxamidomethylation of s-s bond in ranid frog peptides: Pro and contra for de novo MALDI-MS sequencing (2008) crossref
- Accurate Mass as a Bioinformatic Parameter in Data-to-Knowledge Conversion: Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Peptide De Novo Sequencing (2007) crossref
- De Novo Sequencing and Disulfide Mapping of a Bromotryptophan-Containing Conotoxin by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2006) crossref
- Fourier transform mass spectrometry: A powerful tool for toxin analysis (2006) crossref
- Proteomics-Grade de Novo Sequencing Approach (2005) crossref
- Characterization of Toxins within Crude Venoms by Combined Use of Fourier Transform Mass Spectrometry and Cloning (2005) crossref
- De novo sequencing, peptide composition analysis, and composition-based sequencing: A new strategy employing accurate mass determination by Fourier transform ion cyclotron resonance mass spectrometry (2004) crossref
- De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis (2004) crossref
- PAAS 3: A computer program to determine probable sequence of peptides from mass spectrometric data (1984) crossref
Cited by (5)
- EThcD as a Unique Tool for the Top-Down De Novo Sequencing of Intact Natural Ranid Amphibian Peptides (2024) crossref
- Tandem Mass Spectrometry de novo Sequencing of the Skin Defense Peptides of the Central Slovenian Agile Frog Rana dalmatina (2023) both
- Algorithms for de-novo sequencing of peptides by tandem mass spectrometry: A review (2023) crossref
- Mass spectrometry in de novo sequencing of the skin peptides from Arkhangelsk, Russia Rana temporaria: The variability of secreted AMPs in different populations (2023) crossref
- Modern Approaches in de novo Sequencing of Nontryptic Peptides of Ranid and Hylid Frogs by Means of Mass Spectrometry: A Review (2022) crossref